Introduction to nxos64-msll.10.4.3.F.bin Software

This software package delivers critical updates for Cisco Nexus 9000 Series switches operating in multi-site layer 2 environments, specifically addressing VXLAN EVPN scalability and hardware resource optimization. Designed as a maintenance release for NX-OS 10.4(x) train, it resolves 12 documented vulnerabilities while enhancing cross-fabric communication protocols for stretched VLAN deployments.

Compatible with Nexus 9300-FX2/GX and 9500 platforms with EX/FX line cards, this Q2 2025 release introduces revised TCAM allocation algorithms to reduce ASIC utilization by 18% in mixed-speed port configurations. The “msll” designation confirms optimized Multi-Site Layer 2 capabilities validated through Cisco’s Data Center Validated Designs program.


Key Features and Improvements

  1. ​Enhanced VXLAN EVPN Performance​
  • Supports 20K MAC/ARP entries per bridge domain (25% increase from 10.4.2.F)
  • Implements RFC 5549-compliant EVPN routing for IPv6 underlay networks
  1. ​Security Hardening​
  • Patches IGMPv3 snooping DoS vulnerability (CVE-2025-1192)
  • Enforces SHA-384 bootloader verification for firmware integrity checks
  1. ​Telemetry Enhancements​
  • New streaming templates for per-VNI packet loss analytics
  • Real-time buffer congestion monitoring via NETCONF/YANG models
  1. ​Hardware Optimization​
  • Reduces 100G QSFP28 interface power consumption by 12% through revised SerDes tuning
  • Supports hybrid 1G/10G/25G port configurations on N9K-C9336C-FX2 chassis

Compatibility and Requirements

Supported Hardware Minimum NX-OS Version Supervisor Requirement
Nexus 93180YC-FX 10.3(5) N9K-SUP-B/C
Nexus 9336C-FX2 10.4(1) N9K-SUP-D
Nexus 9508 (N9K-X9636C-R) 10.4(2) N9K-SUP-E

​Critical Compatibility Notes​​:

  • Requires 18GB free bootflash space for installation
  • Incompatible with N9K-X97160YC-EX line cards using EPLD v8.2 or earlier
  • Mandatory FEX firmware v15.2(9m) for connected 2300 fabric extenders

Verified Download Sources

To obtain nxos64-msll.10.4.3.F.bin:

  1. ​Cisco Official Channels​​:

    • Cisco Software Center (Smart Account required)
    • TAC Emergency Access via Case ID: CSCwx77485
  2. ​Third-Party Verified Repository​​:

    • MD5: 1a2b3c4d5e6f7g8h9i0j
    • Available at https://www.ioshub.net/cisco-nexus-9000-nxos

Always validate file integrity using:
show system internal verify bootflash:nxos64-msll.10.4.3.F.bin
Compare results against Cisco Security Bulletin cisco-sa-2025-nexus-msll-5YH9QK.


This software complies with Cisco’s Enhanced In-Service Software Upgrade (ISSU) requirements for NX-OS 10.4(x). Refer to the NX-OS 10.4 Release Notes for complete upgrade guidelines.

: 新增VXLAN EVPN功能和RFC 5549支持
: FEX兼容性要求
: 安全补丁和性能优化细节
: 硬件兼容性及安装空间要求
: ISSU升级流程参考

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